LeHavreV1, France, Analysis, bibRecord, 000C61

Evidence of genotoxicity related to high PAH content of sediments in the upper part of the Seine estuary (Normandy, France)

Identifieur interne : 000C61 ( France/Analysis ); précédent : 000C60; suivant : 000C62

Evidence of genotoxicity related to high PAH content of sediments in the upper part of the Seine estuary (Normandy, France)

Auteurs : J. Cachot [France] ; O. Geffard [France] ; S. Augagneur [France] ; S. Lacroix [France] ; K. Le Menach [France] ; L. Peluhet [France] ; J. Couteau [France] ; X. Denier [France] ; M. H. Devier [France] ; D. Pottier [France] ; H. Budzinski [France]

Source :

Aquatic toxicology [ 0166-445X ] ; 2006.

RBID : Pascal:06-0444391

Descripteurs français

Pascal (Inist)
- Génotoxicité, Sédiment, France, Etude sur terrain, Biphényle(polychloro), Métal, Milieu aquatique, Ecotoxicologie, Milieu saumâtre, Composé aromatique polycyclique, Hydrocarbure, Estuaire Seine, Normandie.
Wicri :
- geographic : France.
- topic : Métal, Milieu aquatique, Hydrocarbure.

English descriptors

KwdEn :
- Animals, Aquatic environment, Brackish water environment, Crassostrea (drug effects), Crassostrea (genetics), Ecotoxicology, Embryo, Nonmammalian (drug effects), Field study, France, Genotoxicity, Geologic Sediments (analysis), Hydrocarbon, Hydrocarbons, Chlorinated (analysis), Inhibitory Concentration 50, Metal, Metals, Heavy (analysis), Mutagenicity Tests (methods), Normandy, Polychlorobiphenyl, Polycyclic Hydrocarbons, Aromatic (analysis), Polycyclic Hydrocarbons, Aromatic (toxicity), Polycyclic aromatic compound, Rivers, Sediments, Seine Estuary, Water Pollutants, Chemical (toxicity).
MESH :
- chemical , analysis : Hydrocarbons, Chlorinated, Metals, Heavy, Polycyclic Hydrocarbons, Aromatic.
- chemical , toxicity : Polycyclic Hydrocarbons, Aromatic, Water Pollutants, Chemical.
- geographic : France.
- analysis : Geologic Sediments.
- drug effects : Crassostrea, Embryo, Nonmammalian.
- genetics : Crassostrea.
- methods : Mutagenicity Tests.
- Animals, Inhibitory Concentration 50, Rivers.

Abstract

In order to characterize the genotoxicity in the Seine estuary and Seine bay, chemical and toxicological analyses were performed on 17 sediments collected in June 2001 and June 2003. Many potent mutagenic and/or carcinogenic compounds - including polycyclic aromatic hydrocarbons (PAH), polychlorinated biphenyls (PCB) and metals - were detected. Those compounds were found to be at relatively high concentrations in the upper part of the Seine estuary but were barely detectable at sites outside the plume from the Seine. The levels of pollution did not vary significantly between the two sampling periods, except that PAH concentrations in sediments collected at Oissel and Le Havre showed a marked increase in June 2003. The toxicity of organic extracts from sediments was evaluated by both embryotoxicity and in vitro genotoxicity (SOS Chromotest) assays. Organic extracts from sediments taken from the Seine estuary appeared significantly more embryotoxic than those from the Seine bay. In addition, the sediment extracts from the upper part of the Seine estuary exhibited higher genotoxicity than those from the lower part, and no genotoxicity was reported for sediments from the Seine bay. The genotoxic activity was detected only after adding an S9 microsomal fraction, suggesting the preponderant involvement of pro-genotoxic organic compounds. In addition, SOS Chromotest responses obtained with purified organic fractions revealed that PAH and, to a lesser extent, unknown polar organic compounds were probably responsible for this genotoxicity. Altogether, these results suggest that sediments from the upper Seine estuary are genotoxic and embryotoxic, and therefore, could be potentially hazardous for species living or feeding in the area.

Affiliations:

Links to Exploration step

Pascal:06-0444391

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Evidence of genotoxicity related to high PAH content of sediments in the upper part of the Seine estuary (Normandy, France)</title>
<author><name sortKey="Cachot, J" sort="Cachot, J" uniqKey="Cachot J" first="J." last="Cachot">J. Cachot</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Laboratory of Ecotoxicology (LEMA), UPRES EA-3222, IFRMP 23, University of Le Havre, 25 rue Philippe Lebon, B.P. 540</s1>
<s2>76058 Le Havre</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Normandie</region>
<region type="old region" nuts="2">Haute-Normandie</region>
<settlement type="city">Le Havre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Geffard, O" sort="Geffard, O" uniqKey="Geffard O" first="O." last="Geffard">O. Geffard</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>LPTC UMR-5472 CNRS, University Bordeaux I</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Augagneur, S" sort="Augagneur, S" uniqKey="Augagneur S" first="S." last="Augagneur">S. Augagneur</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>LPTC UMR-5472 CNRS, University Bordeaux I</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lacroix, S" sort="Lacroix, S" uniqKey="Lacroix S" first="S." last="Lacroix">S. Lacroix</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Laboratory of Ecotoxicology (LEMA), UPRES EA-3222, IFRMP 23, University of Le Havre, 25 rue Philippe Lebon, B.P. 540</s1>
<s2>76058 Le Havre</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Normandie</region>
<region type="old region" nuts="2">Haute-Normandie</region>
<settlement type="city">Le Havre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Le Menach, K" sort="Le Menach, K" uniqKey="Le Menach K" first="K." last="Le Menach">K. Le Menach</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>LPTC UMR-5472 CNRS, University Bordeaux I</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Peluhet, L" sort="Peluhet, L" uniqKey="Peluhet L" first="L." last="Peluhet">L. Peluhet</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>LPTC UMR-5472 CNRS, University Bordeaux I</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Couteau, J" sort="Couteau, J" uniqKey="Couteau J" first="J." last="Couteau">J. Couteau</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Laboratory of Ecotoxicology (LEMA), UPRES EA-3222, IFRMP 23, University of Le Havre, 25 rue Philippe Lebon, B.P. 540</s1>
<s2>76058 Le Havre</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Normandie</region>
<region type="old region" nuts="2">Haute-Normandie</region>
<settlement type="city">Le Havre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Denier, X" sort="Denier, X" uniqKey="Denier X" first="X." last="Denier">X. Denier</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Laboratory of Ecotoxicology (LEMA), UPRES EA-3222, IFRMP 23, University of Le Havre, 25 rue Philippe Lebon, B.P. 540</s1>
<s2>76058 Le Havre</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Normandie</region>
<region type="old region" nuts="2">Haute-Normandie</region>
<settlement type="city">Le Havre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Devier, M H" sort="Devier, M H" uniqKey="Devier M" first="M. H." last="Devier">M. H. Devier</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>LPTC UMR-5472 CNRS, University Bordeaux I</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pottier, D" sort="Pottier, D" uniqKey="Pottier D" first="D." last="Pottier">D. Pottier</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>GRECAN EA-1772, University of Caen</s1>
<s2>Caen</s2>
<s3>FRA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Caen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Budzinski, H" sort="Budzinski, H" uniqKey="Budzinski H" first="H." last="Budzinski">H. Budzinski</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>LPTC UMR-5472 CNRS, University Bordeaux I</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">06-0444391</idno>
<date when="2006">2006</date>
<idno type="stanalyst">PASCAL 06-0444391 INIST</idno>
<idno type="RBID">Pascal:06-0444391</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000179</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000162</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000204</idno>
<idno type="wicri:doubleKey">0166-445X:2006:Cachot J:evidence:of:genotoxicity</idno>
<idno type="wicri:Area/Main/Merge">001206</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:16887205</idno>
<idno type="wicri:Area/PubMed/Corpus">000284</idno>
<idno type="wicri:Area/PubMed/Curation">000284</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000284</idno>
<idno type="wicri:Area/Ncbi/Merge">000163</idno>
<idno type="wicri:Area/Ncbi/Curation">000163</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000163</idno>
<idno type="wicri:doubleKey">0166-445X:2006:Cachot J:evidence:of:genotoxicity</idno>
<idno type="wicri:Area/Main/Merge">001089</idno>
<idno type="wicri:Area/Main/Curation">001184</idno>
<idno type="wicri:Area/Main/Exploration">001184</idno>
<idno type="wicri:Area/France/Extraction">000C61</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Evidence of genotoxicity related to high PAH content of sediments in the upper part of the Seine estuary (Normandy, France)</title>
<author><name sortKey="Cachot, J" sort="Cachot, J" uniqKey="Cachot J" first="J." last="Cachot">J. Cachot</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Laboratory of Ecotoxicology (LEMA), UPRES EA-3222, IFRMP 23, University of Le Havre, 25 rue Philippe Lebon, B.P. 540</s1>
<s2>76058 Le Havre</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Normandie</region>
<region type="old region" nuts="2">Haute-Normandie</region>
<settlement type="city">Le Havre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Geffard, O" sort="Geffard, O" uniqKey="Geffard O" first="O." last="Geffard">O. Geffard</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>LPTC UMR-5472 CNRS, University Bordeaux I</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Augagneur, S" sort="Augagneur, S" uniqKey="Augagneur S" first="S." last="Augagneur">S. Augagneur</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>LPTC UMR-5472 CNRS, University Bordeaux I</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lacroix, S" sort="Lacroix, S" uniqKey="Lacroix S" first="S." last="Lacroix">S. Lacroix</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Laboratory of Ecotoxicology (LEMA), UPRES EA-3222, IFRMP 23, University of Le Havre, 25 rue Philippe Lebon, B.P. 540</s1>
<s2>76058 Le Havre</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Normandie</region>
<region type="old region" nuts="2">Haute-Normandie</region>
<settlement type="city">Le Havre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Le Menach, K" sort="Le Menach, K" uniqKey="Le Menach K" first="K." last="Le Menach">K. Le Menach</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>LPTC UMR-5472 CNRS, University Bordeaux I</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Peluhet, L" sort="Peluhet, L" uniqKey="Peluhet L" first="L." last="Peluhet">L. Peluhet</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>LPTC UMR-5472 CNRS, University Bordeaux I</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Couteau, J" sort="Couteau, J" uniqKey="Couteau J" first="J." last="Couteau">J. Couteau</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Laboratory of Ecotoxicology (LEMA), UPRES EA-3222, IFRMP 23, University of Le Havre, 25 rue Philippe Lebon, B.P. 540</s1>
<s2>76058 Le Havre</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Normandie</region>
<region type="old region" nuts="2">Haute-Normandie</region>
<settlement type="city">Le Havre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Denier, X" sort="Denier, X" uniqKey="Denier X" first="X." last="Denier">X. Denier</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Laboratory of Ecotoxicology (LEMA), UPRES EA-3222, IFRMP 23, University of Le Havre, 25 rue Philippe Lebon, B.P. 540</s1>
<s2>76058 Le Havre</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Normandie</region>
<region type="old region" nuts="2">Haute-Normandie</region>
<settlement type="city">Le Havre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Devier, M H" sort="Devier, M H" uniqKey="Devier M" first="M. H." last="Devier">M. H. Devier</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>LPTC UMR-5472 CNRS, University Bordeaux I</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pottier, D" sort="Pottier, D" uniqKey="Pottier D" first="D." last="Pottier">D. Pottier</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>GRECAN EA-1772, University of Caen</s1>
<s2>Caen</s2>
<s3>FRA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Caen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Budzinski, H" sort="Budzinski, H" uniqKey="Budzinski H" first="H." last="Budzinski">H. Budzinski</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>LPTC UMR-5472 CNRS, University Bordeaux I</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Aquatic toxicology</title>
<title level="j" type="abbreviated">Aquat. toxicol.</title>
<idno type="ISSN">0166-445X</idno>
<imprint><date when="2006">2006</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Aquatic toxicology</title>
<title level="j" type="abbreviated">Aquat. toxicol.</title>
<idno type="ISSN">0166-445X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Aquatic environment</term>
<term>Brackish water environment</term>
<term>Crassostrea (drug effects)</term>
<term>Crassostrea (genetics)</term>
<term>Ecotoxicology</term>
<term>Embryo, Nonmammalian (drug effects)</term>
<term>Field study</term>
<term>France</term>
<term>Genotoxicity</term>
<term>Geologic Sediments (analysis)</term>
<term>Hydrocarbon</term>
<term>Hydrocarbons, Chlorinated (analysis)</term>
<term>Inhibitory Concentration 50</term>
<term>Metal</term>
<term>Metals, Heavy (analysis)</term>
<term>Mutagenicity Tests (methods)</term>
<term>Normandy</term>
<term>Polychlorobiphenyl</term>
<term>Polycyclic Hydrocarbons, Aromatic (analysis)</term>
<term>Polycyclic Hydrocarbons, Aromatic (toxicity)</term>
<term>Polycyclic aromatic compound</term>
<term>Rivers</term>
<term>Sediments</term>
<term>Seine Estuary</term>
<term>Water Pollutants, Chemical (toxicity)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Hydrocarbons, Chlorinated</term>
<term>Metals, Heavy</term>
<term>Polycyclic Hydrocarbons, Aromatic</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Polycyclic Hydrocarbons, Aromatic</term>
<term>Water Pollutants, Chemical</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>France</term>
</keywords>
<keywords scheme="MESH" qualifier="analysis" xml:lang="en"><term>Geologic Sediments</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Crassostrea</term>
<term>Embryo, Nonmammalian</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Crassostrea</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Mutagenicity Tests</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Inhibitory Concentration 50</term>
<term>Rivers</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Génotoxicité</term>
<term>Sédiment</term>
<term>France</term>
<term>Etude sur terrain</term>
<term>Biphényle(polychloro)</term>
<term>Métal</term>
<term>Milieu aquatique</term>
<term>Ecotoxicologie</term>
<term>Milieu saumâtre</term>
<term>Composé aromatique polycyclique</term>
<term>Hydrocarbure</term>
<term>Estuaire Seine</term>
<term>Normandie</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>France</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Métal</term>
<term>Milieu aquatique</term>
<term>Hydrocarbure</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">In order to characterize the genotoxicity in the Seine estuary and Seine bay, chemical and toxicological analyses were performed on 17 sediments collected in June 2001 and June 2003. Many potent mutagenic and/or carcinogenic compounds - including polycyclic aromatic hydrocarbons (PAH), polychlorinated biphenyls (PCB) and metals - were detected. Those compounds were found to be at relatively high concentrations in the upper part of the Seine estuary but were barely detectable at sites outside the plume from the Seine. The levels of pollution did not vary significantly between the two sampling periods, except that PAH concentrations in sediments collected at Oissel and Le Havre showed a marked increase in June 2003. The toxicity of organic extracts from sediments was evaluated by both embryotoxicity and in vitro genotoxicity (SOS Chromotest) assays. Organic extracts from sediments taken from the Seine estuary appeared significantly more embryotoxic than those from the Seine bay. In addition, the sediment extracts from the upper part of the Seine estuary exhibited higher genotoxicity than those from the lower part, and no genotoxicity was reported for sediments from the Seine bay. The genotoxic activity was detected only after adding an S9 microsomal fraction, suggesting the preponderant involvement of pro-genotoxic organic compounds. In addition, SOS Chromotest responses obtained with purified organic fractions revealed that PAH and, to a lesser extent, unknown polar organic compounds were probably responsible for this genotoxicity. Altogether, these results suggest that sediments from the upper Seine estuary are genotoxic and embryotoxic, and therefore, could be potentially hazardous for species living or feeding in the area.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Haute-Normandie</li>
<li>Région Normandie</li>
</region>
<settlement><li>Bordeaux</li>
<li>Caen</li>
<li>Le Havre</li>
</settlement>
</list>
<tree><country name="France"><region name="Région Normandie"><name sortKey="Cachot, J" sort="Cachot, J" uniqKey="Cachot J" first="J." last="Cachot">J. Cachot</name>
</region>
<name sortKey="Augagneur, S" sort="Augagneur, S" uniqKey="Augagneur S" first="S." last="Augagneur">S. Augagneur</name>
<name sortKey="Budzinski, H" sort="Budzinski, H" uniqKey="Budzinski H" first="H." last="Budzinski">H. Budzinski</name>
<name sortKey="Couteau, J" sort="Couteau, J" uniqKey="Couteau J" first="J." last="Couteau">J. Couteau</name>
<name sortKey="Denier, X" sort="Denier, X" uniqKey="Denier X" first="X." last="Denier">X. Denier</name>
<name sortKey="Devier, M H" sort="Devier, M H" uniqKey="Devier M" first="M. H." last="Devier">M. H. Devier</name>
<name sortKey="Geffard, O" sort="Geffard, O" uniqKey="Geffard O" first="O." last="Geffard">O. Geffard</name>
<name sortKey="Lacroix, S" sort="Lacroix, S" uniqKey="Lacroix S" first="S." last="Lacroix">S. Lacroix</name>
<name sortKey="Le Menach, K" sort="Le Menach, K" uniqKey="Le Menach K" first="K." last="Le Menach">K. Le Menach</name>
<name sortKey="Peluhet, L" sort="Peluhet, L" uniqKey="Peluhet L" first="L." last="Peluhet">L. Peluhet</name>
<name sortKey="Pottier, D" sort="Pottier, D" uniqKey="Pottier D" first="D." last="Pottier">D. Pottier</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/France/explor/LeHavreV1/Data/France/Analysis

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C61 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000C61 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/France
   |area=    LeHavreV1
   |flux=    France
   |étape=   Analysis
   |type=    RBID
   |clé=     Pascal:06-0444391
   |texte=   Evidence of genotoxicity related to high PAH content of sediments in the upper part of the Seine estuary (Normandy, France)
}}

This area was generated with Dilib version V0.6.25.
Data generation: Sat Dec 3 14:37:02 2016. Site generation: Tue Mar 5 08:25:07 2024

Serveur d'exploration sur la visibilité du Havre

Evidence of genotoxicity related to high PAH content of sediments in the upper part of the Seine estuary (Normandy, France)

Evidence of genotoxicity related to high PAH content of sediments in the upper part of the Seine estuary (Normandy, France)

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Serveur d'exploration sur la visibilité du Havre
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.